Government provides £2.1 million investment to University of Oxford trial.
Several promising treatments being trialled which have the potential to benefit hundreds of thousands of people worldwide.
The world’s largest randomised clinical trial of potential coronavirus treatments is well underway in the UK as part of the race to find a treatment.
Almost 1,000 patients from 132 different hospitals have been already recruited in just 15 days and thousands more are expected to join the Randomised Evaluation of COV-id19 thERapY (RECOVERY) trial in the coming weeks, making it the largest randomised controlled trial of potential COVID-19 treatments in the world.
The malaria drug hydroxychloroquine helped to speed the recovery of a small number of patients who were mildly ill from the coronavirus, doctors in China reported this week.
Cough, fever and pneumonia went away faster, and the disease seemed less likely to turn severe in people who received hydroxychloroquine than in a comparison group not given the drug. The authors of the report said that the medication was promising, but that more research was needed to clarify how it might work in treating coronavirus disease and to determine the best way to use it.
“It’s going to send a ripple of excitement out through the treating community,” said Dr. William Schaffner, an infectious disease expert at Vanderbilt University.
The study was small and limited to patients who were mildly or moderately ill, not severe cases. Like many reports about the coronavirus, it was posted at medRxiv, an online server for medical articles, before undergoing peer review by other researchers.
But the findings strongly support earlier studies suggesting a role for the drug, Dr. Schaffner said.
Scientists across the country were still in search of a cure for the coronavirus disease 2019, or COVID-19, on Tuesday, March 31, 2020. Clinical trials were underway as doctors tried to find a way to treat the deadly virus.
Marcus Zervos, infectious disease doctor for Henry Ford Health System, said they had seen success with hydroxychloroquine therapy in a number of COVID-19 patients. He said those given the drug were able to get off a ventilator and out of the hospital faster.
“The goal of therapy is to take patients that have shortness of breath, compromised respiratory status, that have pneumonia, and by treating them with hydroxychloroquine, prevent them from the complication of progression of infection, ending up in an intensive care unit or ending up on a ventilator," Zervos said.
Zervos said it typically took patients hospitalized with COVID-19 between two and four weeks to recover. He said hydroxychloroquine therapy was reducing that recovery time.
Novartis commits to donate up to 130 million doses of hydroxychloroquine to support the global COVID-19 pandemic response
Novartis announced today its commitment to donate up to 130 million doses of generic hydroxychloroquine to support the global COVID-19 pandemic response. Hydroxychloroquine and a related drug, chloroquine, are currently under evaluation in clinical trials for the treatment of COVID-19. Novartis is supporting ongoing clinical trial efforts, and will evaluate needs for additional clinical trials.
When supported for use in COVID-19 infected patients by regulatory authorities, Novartis intends to donate up to 130 million 200 mg doses by the end of May, including its current stock of 50 million 200 mg doses. The company is also exploring further scaling of capacity to increase supply and is committed to working with manufacturers around the world to meet global demand.
As New York State continues to see a rise in cases of the novel coronavirus and is the epicenter of the pandemic in the United States, clinical trials for drug treatments began on Tuesday in the state.
The state acquired 70,000 doses of hydroxychloroquine, 10,000 doses of zithromax and 750,000 doses of chloroquine in the last few days, according to a news release by New York Gov. Andrew Cuomo’s office.
"We hope for optimistic results," Cuomo said during a press conference Tuesday, talking about the clinical trials. "The president and the FDA accelerated that drug coming to New York so the hospitals will start using that drug today."
Nearly 70 drugs and experimental compounds may be effective in treating the coronavirus, a team of researchers reported on Sunday night. Some of the medications are already used to treat other diseases, and repurposing them to treat Covid-19, the illness caused by the coronavirus, may be faster than trying to invent a new antiviral from scratch, the scientists said.
A drug combo already used against HIV. A malaria treatment first tested during World War II. A new antiviral whose promise against Ebola fizzled last year. Could any of these drugs hold the key to saving COVID-19 patients from serious harm or death?
On Friday, the World Health Organization (WHO) announced a large global trial, called SOLIDARITY, to find out if any can treat infections with the new coronavirus for the dangerous respiratory disease.
There are currently in excess of 60 clinical trials underway for COVID-19. You can find a list of them here - https://www.genengnews.com/virology/coronavirus/catching-up-to-coronavirus-top-60-treatments-in-development/
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